Expression of SHKBP1 in cancer - Summary - The Human Protein Atlas

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SHKBP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SHKBP1
Gene description	SH3KBP1 binding protein 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA041887
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041887

GENE INFORMATION
Gene name	SHKBP1 (HGNC Symbol)
Synonyms	PP203, Sb1
Description	SH3KBP1 binding protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40576851 - 40591399
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160410 (version 83.38)
Entrez gene	92799
UniProt	Q8TBC3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TBC3
Antibodypedia	SHKBP1 antibodies

PROTEIN BROWSER

SHKBP1-001	SHKBP1-002	SHKBP1-003	SHKBP1-008	SHKBP1-010	SHKBP1-011	SHKBP1-019	SHKBP1-020	SHKBP1-027	SHKBP1-028	SHKBP1-029

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SHKBP1-001 ENSP00000291842 ENST00000291842	Q8TBC3 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0051260 [protein homooligomerization] Show all	707 aa 76.3 kDa	No	0
SHKBP1-002 ENSP00000472711 ENST00000600733	M0R2P6 [Direct mapping] SH3KBP1 binding protein 1, isoform CRA_c; SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0051260 [protein homooligomerization] Show all	682 aa 73.7 kDa	No	0
SHKBP1-003 ENSP00000471406 ENST00000600718	M0R0S1 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0051260 [protein homooligomerization] Show all	610 aa 65.9 kDa	No	0
SHKBP1-008 ENSP00000471296 ENST00000594298	M0R0K4 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		175 aa 18.5 kDa	No	0
SHKBP1-010 ENSP00000470505 ENST00000595726	M0QZE8 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 17 kDa	Yes	0
SHKBP1-011 ENSP00000471173 ENST00000593764	M0R0E3 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	262 aa 28 kDa	No	0
SHKBP1-019 ENSP00000469713 ENST00000600320	M0QYB1 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	250 aa 26.5 kDa	No	0
SHKBP1-020 ENSP00000470517 ENST00000602011	M0QZF4 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		299 aa 31.8 kDa	No	0
SHKBP1-027 ENSP00000469014 ENST00000595631	M0QXA4 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 14.3 kDa	No	0
SHKBP1-028 ENSP00000471408 ENST00000597396	M0R0S2 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		277 aa 29.5 kDa	No	0
SHKBP1-029 ENSP00000471845 ENST00000594862	M0R1G0 [Direct mapping] SH3KBP1-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 15 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.