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A majority of malignant cells displayed weak to moderate cytoplasmic staining.Cases of colorectal, prostate and hepatocellular carcinomas showed strong cytoplasmic positivity. Most malignant gliomas, malignant lymphomas, endometrial, gastric, skin, testicular and pancreatic cancers were however negative.
This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]