Expression of ZER1 in cancer - Summary - The Human Protein Atlas

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ZER1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	ZER1
Gene description	Zyg-11 related, cell cycle regulator
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	ZER1 (HGNC Symbol)
Synonyms	C9orf60, Hzyg, ZYG, ZYG11BL
Description	Zyg-11 related, cell cycle regulator (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	128729786 - 128772414
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160445 (version 83.38)
Entrez gene	10444
UniProt	Q7Z7L7 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z7L7
Antibodypedia	ZER1 antibodies

PROTEIN BROWSER

ZER1-001	ZER1-002	ZER1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZER1-001 ENSP00000291900 ENST00000291900	Q7Z7L7 [Direct mapping] Protein zer-1 homolog A0A024R8B0 [Target identity:100%; Query identity:100%] Zyg-11 homolog B (C. elegans)-like, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0051438 [regulation of ubiquitin-protein transferase activity] Show all	766 aa 88.2 kDa	No	0
ZER1-002 ENSP00000389271 ENST00000427848	X6RC68 [Direct mapping] Protein zer-1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.7 kDa	No	0
ZER1-003 ENSP00000393051 ENST00000414921	X6RD87 [Direct mapping] Protein zer-1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 18.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.