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PKN3

GENERAL INFORMATION

Gene name

 PKN3

Gene description

 Protein kinase N3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA045390 , HPA058305
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045390
HPA058305

GENE INFORMATION

Gene name

 PKN3 (HGNC Symbol)

Synonyms

 PKNbeta, UTDP4-1

Description

 Protein kinase N3 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128702523 - 128720918

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160447 (version 83.38)

Entrez gene

 29941

UniProt

 Q6P5Z2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P5Z2

Antibodypedia

 PKN3 antibodies

PROTEIN BROWSER
PKN3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKN3-001
ENSP00000291906
ENST00000291906
Q6P5Z2 [Direct mapping]
Serine/threonine-protein kinase N3
A0A024R8D6 [Target identity:100%; Query identity:100%]
Protein kinase N3, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0010631 [epithelial cell migration]
GO:0048471 [perinuclear region of cytoplasm]
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 889 aa
99.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.