Expression of PLPP7 in cancer - Summary - The Human Protein Atlas

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PLPP7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLPP7
Gene description	Phospholipid phosphatase 7 (inactive)
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AN3-CA, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including heart and skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA070252
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA070252

GENE INFORMATION
Gene name	PLPP7 (HGNC Symbol)
Synonyms	C9orf67, FLJ14662, MGC12921, NET39, PPAPDC3
Description	Phospholipid phosphatase 7 (inactive) (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q34.13
Chromosome location (bp)	131289694 - 131309262
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160539 (version 83.38)
Entrez gene	84814
UniProt	Q8NBV4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NBV4
Antibodypedia	PLPP7 antibodies

PROTEIN BROWSER

PLPP7-001	PLPP7-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLPP7-001 ENSP00000361338 ENST00000372264	Q8NBV4 [Direct mapping] Probable lipid phosphate phosphatase PPAPDC3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005635 [nuclear envelope] GO:0005789 [endoplasmic reticulum membrane] GO:0008152 [metabolic process] GO:0010832 [negative regulation of myotube differentiation] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	271 aa 29.4 kDa	No	4
PLPP7-002 ENSP00000361335 ENST00000372261	X6R886 [Direct mapping] Probable lipid phosphate phosphatase PPAPDC3 Show all	Predicted intracellular proteins Show all		151 aa 16.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.