Expression of AMICA1 in cancer - Summary - The Human Protein Atlas

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AMICA1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AMICA1
Gene description	Adhesion molecule, interacts with CXADR antigen 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (CACO-2, HMC-1)
HPA (normal tissue):	Tissue enhanced (appendix)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA047919
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and lung cancer (favourable).
Head and neck cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047919

GENE INFORMATION
Gene name	AMICA1 (HGNC Symbol)
Synonyms	AMICA, Gm638
Description	Adhesion molecule, interacts with CXADR antigen 1 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118193740 - 118225094
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160593 (version 83.38)
Entrez gene	120425
UniProt	Q86YT9 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YT9
Antibodypedia	AMICA1 antibodies

PROTEIN BROWSER

AMICA1-001	AMICA1-002	AMICA1-003	AMICA1-004	AMICA1-009	AMICA1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMICA1-001 ENSP00000348635 ENST00000356289	Q86YT9 [Direct mapping] Junctional adhesion molecule-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0030593 [neutrophil chemotaxis] GO:0035696 [monocyte extravasation] GO:0042803 [protein homodimerization activity] GO:0046629 [gamma-delta T cell activation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0060054 [positive regulation of epithelial cell proliferation involved in wound healing] GO:0072672 [neutrophil extravasation] Show all	394 aa 44.3 kDa	Yes	1
AMICA1-002 ENSP00000431218 ENST00000526620	Q86YT9 [Direct mapping] Junctional adhesion molecule-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0030593 [neutrophil chemotaxis] GO:0035696 [monocyte extravasation] GO:0042803 [protein homodimerization activity] GO:0046629 [gamma-delta T cell activation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0060054 [positive regulation of epithelial cell proliferation involved in wound healing] GO:0072672 [neutrophil extravasation] Show all	355 aa 40.1 kDa	No	1
AMICA1-003 ENSP00000292067 ENST00000292067	Q86YT9 [Direct mapping] Junctional adhesion molecule-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0030593 [neutrophil chemotaxis] GO:0035696 [monocyte extravasation] GO:0042803 [protein homodimerization activity] GO:0046629 [gamma-delta T cell activation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0060054 [positive regulation of epithelial cell proliferation involved in wound healing] GO:0072672 [neutrophil extravasation] Show all	384 aa 43.1 kDa	No	1
AMICA1-004 ENSP00000436117 ENST00000533261	E9PR26 [Direct mapping] Junctional adhesion molecule-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0046629 [gamma-delta T cell activation] GO:0050900 [leukocyte migration] Show all	383 aa 43 kDa	Yes	1
AMICA1-009 ENSP00000431791 ENST00000525565	E9PJJ4 [Direct mapping] Junctional adhesion molecule-like Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0046629 [gamma-delta T cell activation] GO:0050900 [leukocyte migration] Show all	155 aa 17.3 kDa	Yes	0
AMICA1-011 ENSP00000432769 ENST00000524477	E9PNS8 [Direct mapping] Junctional adhesion molecule-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0046629 [gamma-delta T cell activation] GO:0050900 [leukocyte migration] Show all	121 aa 13.7 kDa	No	0

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The Human Protein Atlas

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