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IL6R

GENERAL INFORMATION

Gene name

 IL6R

Gene description

 Interleukin 6 receptor

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
CD markers
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IL6R (HGNC Symbol)

Synonyms

 CD126

Description

 Interleukin 6 receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 154405193 - 154469450

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160712 (version 83.38)

Entrez gene

 3570

UniProt

 P08887 (UniProt - Evidence at protein level)

neXtProt

 NX_P08887

Antibodypedia

 IL6R antibodies

PROTEIN BROWSER
IL6R-001
IL6R-002
IL6R-003
IL6R-004
IL6R-007
IL6R-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL6R-001
ENSP00000357470
ENST00000368485
P08887 [Direct mapping]
Interleukin-6 receptor subunit alpha
A0N0L5 [Target identity:100%; Query identity:100%]
Interleukin 6 receptor; Interleukin 6 receptor, isoform CRA_a
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002384 [hepatic immune response]
GO:0002446 [neutrophil mediated immunity]
GO:0002548 [monocyte chemotaxis]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0004915 [interleukin-6 receptor activity]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005896 [interleukin-6 receptor complex]
GO:0006953 [acute-phase response]
GO:0008284 [positive regulation of cell proliferation]
GO:0010536 [positive regulation of activation of Janus kinase activity]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019981 [interleukin-6 binding]
GO:0031018 [endocrine pancreas development]
GO:0032717 [negative regulation of interleukin-8 production]
GO:0032722 [positive regulation of chemokine production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032966 [negative regulation of collagen biosynthetic process]
GO:0034097 [response to cytokine]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070119 [ciliary neurotrophic factor binding]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
Show all
 468 aa
51.5 kDa 		Yes 1
IL6R-002
ENSP00000423668
ENST00000476006
H0Y9B1 [Direct mapping]
Interleukin-6 receptor subunit alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 294 aa
32.9 kDa 		No 0
IL6R-003
ENSP00000340589
ENST00000344086
P08887 [Direct mapping]
Interleukin-6 receptor subunit alpha
Show all
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002384 [hepatic immune response]
GO:0002446 [neutrophil mediated immunity]
GO:0002548 [monocyte chemotaxis]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0004915 [interleukin-6 receptor activity]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005896 [interleukin-6 receptor complex]
GO:0006953 [acute-phase response]
GO:0008284 [positive regulation of cell proliferation]
GO:0010536 [positive regulation of activation of Janus kinase activity]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019981 [interleukin-6 binding]
GO:0031018 [endocrine pancreas development]
GO:0032717 [negative regulation of interleukin-8 production]
GO:0032722 [positive regulation of chemokine production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032966 [negative regulation of collagen biosynthetic process]
GO:0034097 [response to cytokine]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070119 [ciliary neurotrophic factor binding]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
Show all
 365 aa
40.2 kDa 		Yes 0
IL6R-004
ENSP00000423184
ENST00000512471
D6R9R8 [Direct mapping]
Interleukin-6 receptor subunit alpha
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 171 aa
18 kDa 		Yes 0
IL6R-007
ENSP00000423036
ENST00000515190
H0Y949 [Direct mapping]
Interleukin-6 receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 190 aa
21.2 kDa 		No 1
IL6R-201
ENSP00000477739
ENST00000622330
A0A087WTB5 [Direct mapping]
Interleukin-6 receptor subunit alpha
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 352 aa
38.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.