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UBE2Q1

GENERAL INFORMATION

Gene name

 UBE2Q1

Gene description

 Ubiquitin-conjugating enzyme E2Q family member 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA063368
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), thyroid cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Thyroid cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA063368

GENE INFORMATION

Gene name

 UBE2Q1 (HGNC Symbol)

Synonyms

 NICE-5, PRO3094, UBE2Q

Description

 Ubiquitin-conjugating enzyme E2Q family member 1 (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 154548577 - 154559028

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160714 (version 83.38)

Entrez gene

 55585

UniProt

 Q7Z7E8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z7E8

Antibodypedia

 UBE2Q1 antibodies

PROTEIN BROWSER
UBE2Q1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2Q1-001
ENSP00000292211
ENST00000292211
Q7Z7E8 [Direct mapping]
Ubiquitin-conjugating enzyme E2 Q1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001967 [suckling behavior]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007566 [embryo implantation]
GO:0007617 [mating behavior]
GO:0009566 [fertilization]
GO:0016567 [protein ubiquitination]
GO:0030175 [filopodium]
GO:0061458 [reproductive system development]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070459 [prolactin secretion]
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 422 aa
46.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.