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CHRNB2

GENERAL INFORMATION

Gene name

 CHRNB2

Gene description

 Cholinergic receptor, nicotinic, beta 2 (neuronal)

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, retina)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, retina)

GENE INFORMATION

Gene name

 CHRNB2

Synonyms

Description

 Cholinergic receptor, nicotinic, beta 2 (neuronal) (HGNC Symbol)

Entrez gene summary

 Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 154567781 - 154580026

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160716 (version 83.38)

Entrez gene

 1141

UniProt

 P17787 (UniProt - Evidence at protein level)

neXtProt

 NX_P17787

Antibodypedia

 CHRNB2 antibodies

PROTEIN BROWSER
CHRNB2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRNB2-001
ENSP00000357461
ENST00000368476
P17787 [Direct mapping]
Neuronal acetylcholine receptor subunit beta-2
Q5SXY3 [Target identity:100%; Query identity:100%]
Cholinergic receptor, nicotinic, beta 2 (Neuronal); cDNA, FLJ94017, Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 2(neuronal) (CHRNB2), mRNA
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001508 [action potential]
GO:0001661 [conditioned taste aversion]
GO:0001666 [response to hypoxia]
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005892 [acetylcholine-gated channel complex]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0007601 [visual perception]
GO:0007605 [sensory perception of sound]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008144 [drug binding]
GO:0008306 [associative learning]
GO:0008542 [visual learning]
GO:0009897 [external side of plasma membrane]
GO:0014059 [regulation of dopamine secretion]
GO:0015276 [ligand-gated ion channel activity]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0021562 [vestibulocochlear nerve development]
GO:0021631 [optic nerve morphogenesis]
GO:0021771 [lateral geniculate nucleus development]
GO:0021952 [central nervous system projection neuron axonogenesis]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0030054 [cell junction]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032225 [regulation of synaptic transmission, dopaminergic]
GO:0032226 [positive regulation of synaptic transmission, dopaminergic]
GO:0033603 [positive regulation of dopamine secretion]
GO:0034220 [ion transmembrane transport]
GO:0035094 [response to nicotine]
GO:0035095 [behavioral response to nicotine]
GO:0035176 [social behavior]
GO:0042053 [regulation of dopamine metabolic process]
GO:0042113 [B cell activation]
GO:0042166 [acetylcholine binding]
GO:0042220 [response to cocaine]
GO:0042320 [regulation of circadian sleep/wake cycle, REM sleep]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045188 [regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0045759 [negative regulation of action potential]
GO:0046982 [protein heterodimerization activity]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050877 [neurological system process]
GO:0050890 [cognition]
GO:0051291 [protein heterooligomerization]
GO:0051899 [membrane depolarization]
GO:0051963 [regulation of synapse assembly]
GO:0060084 [synaptic transmission involved in micturition]
GO:0098655 [cation transmembrane transport]
Show all
 502 aa
57 kDa 		Yes 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.