Expression of ANO10 in cancer - Summary - The Human Protein Atlas

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ANO10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANO10
Gene description	Anoctamin 10
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, some tissues show membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051569
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (favourable), liver cancer (unfavourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051569

GENE INFORMATION
Gene name	ANO10 (HGNC Symbol)
Synonyms	FLJ10375, MGC47890, SCAR10, TMEM16K
Description	Anoctamin 10 (HGNC Symbol)
Entrez gene summary	The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Chromosome	3
Cytoband
Chromosome location (bp)	43354859 - 43691594
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160746 (version 83.38)
Entrez gene	55129
UniProt	Q9NW15 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NW15
Antibodypedia	ANO10 antibodies

PROTEIN BROWSER

ANO10-001	ANO10-002	ANO10-003	ANO10-004	ANO10-005	ANO10-007	ANO10-008	ANO10-009	ANO10-010	ANO10-011	ANO10-012	ANO10-013	ANO10-014	ANO10-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANO10-001 ENSP00000292246 ENST00000292246	Q9NW15 [Direct mapping] Anoctamin-10 A0A024R2S0 [Target identity:100%; Query identity:100%] Anoctamin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	660 aa 76.3 kDa	No	8
ANO10-002 ENSP00000327767 ENST00000350459	Q9NW15 [Direct mapping] Anoctamin-10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	470 aa 53.8 kDa	No	4
ANO10-003 ENSP00000379398 ENST00000396091	Q9NW15 [Direct mapping] Anoctamin-10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	594 aa 68.7 kDa	No	8
ANO10-004 ENSP00000396990 ENST00000414522	Q9NW15 [Direct mapping] Anoctamin-10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	627 aa 72.1 kDa	No	7
ANO10-005 ENSP00000394119 ENST00000451430	Q9NW15 [Direct mapping] Anoctamin-10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	549 aa 63.5 kDa	No	8
ANO10-007 ENSP00000412997 ENST00000448045	H7C3N6 [Direct mapping] Anoctamin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	188 aa 20.7 kDa	Yes	3
ANO10-008 ENSP00000406432 ENST00000427171	C9J670 [Direct mapping] Anoctamin-10 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		192 aa 22 kDa	No	0
ANO10-009 ENSP00000416266 ENST00000428472	C9JH90 [Direct mapping] Anoctamin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	162 aa 19 kDa	No	2
ANO10-010 ENSP00000402010 ENST00000444344	C9JPY2 [Direct mapping] Anoctamin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 16.8 kDa	No	0
ANO10-011 ENSP00000402845 ENST00000456438	C9JQC9 [Direct mapping] Anoctamin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 16.2 kDa	No	0
ANO10-012 ENSP00000399103 ENST00000413397	C9IYD3 [Direct mapping] Anoctamin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 16.1 kDa	No	0
ANO10-013 ENSP00000397360 ENST00000439141	C9JA49 [Direct mapping] Anoctamin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 15.4 kDa	No	0
ANO10-014 ENSP00000406712 ENST00000428831	C9IZD0 [Direct mapping] Anoctamin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 12.8 kDa	No	0
ANO10-015 ENSP00000404988 ENST00000436073	C9JJS5 [Direct mapping] Anoctamin-10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.3 kDa	No	0

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The Human Protein Atlas

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