Tissue expression of FDPS - Summary - The Human Protein Atlas

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FDPS

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FDPS
Gene description	Farnesyl diphosphate synthase
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA028200
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FDPS
Synonyms
Description	Farnesyl diphosphate synthase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155308748 - 155320666
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160752 (version 83.38)
Entrez gene	2224
UniProt	P14324 (UniProt - Evidence at protein level)
neXtProt	NX_P14324
Antibodypedia	FDPS antibodies

PROTEIN BROWSER

FDPS-001	FDPS-002	FDPS-004	FDPS-007	FDPS-019	FDPS-020	FDPS-021	FDPS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FDPS-001 ENSP00000349078 ENST00000356657	P14324 [Direct mapping] Farnesyl pyrophosphate synthase Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004161 [dimethylallyltranstransferase activity] GO:0004337 [geranyltranstransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0016032 [viral process] GO:0033384 [geranyl diphosphate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045337 [farnesyl diphosphate biosynthetic process] GO:0046872 [metal ion binding] Show all	419 aa 48.3 kDa	No	0
FDPS-002 ENSP00000357340 ENST00000368356	P14324 [Direct mapping] Farnesyl pyrophosphate synthase Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004161 [dimethylallyltranstransferase activity] GO:0004337 [geranyltranstransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0016032 [viral process] GO:0033384 [geranyl diphosphate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045337 [farnesyl diphosphate biosynthetic process] GO:0046872 [metal ion binding] Show all	419 aa 48.3 kDa	No	0
FDPS-004 ENSP00000479557 ENST00000491013	A0A087WVN4 [Direct mapping] Farnesyl pyrophosphate synthase Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008299 [isoprenoid biosynthetic process] GO:0016740 [transferase activity] Show all	274 aa 31.8 kDa	No	0
FDPS-007 ENSP00000484099 ENST00000465559	A0A087X1D8 [Direct mapping] Farnesyl pyrophosphate synthase Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008299 [isoprenoid biosynthetic process] Show all	174 aa 20 kDa	No	0
FDPS-019 ENSP00000478235 ENST00000612683	P14324 [Direct mapping] Farnesyl pyrophosphate synthase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004161 [dimethylallyltranstransferase activity] GO:0004337 [geranyltranstransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0016032 [viral process] GO:0033384 [geranyl diphosphate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045337 [farnesyl diphosphate biosynthetic process] GO:0046872 [metal ion binding] Show all	353 aa 40.5 kDa	No	0
FDPS-020 ENSP00000480142 ENST00000467076	P14324 [Direct mapping] Farnesyl pyrophosphate synthase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004161 [dimethylallyltranstransferase activity] GO:0004337 [geranyltranstransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0016032 [viral process] GO:0033384 [geranyl diphosphate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045337 [farnesyl diphosphate biosynthetic process] GO:0046872 [metal ion binding] Show all	353 aa 40.5 kDa	No	0
FDPS-021 ENSP00000391755 ENST00000447866	P14324 [Direct mapping] Farnesyl pyrophosphate synthase Show all	Enzymes ENZYME proteins Transferases TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004161 [dimethylallyltranstransferase activity] GO:0004337 [geranyltranstransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0016032 [viral process] GO:0033384 [geranyl diphosphate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045337 [farnesyl diphosphate biosynthetic process] GO:0046872 [metal ion binding] Show all	353 aa 40.5 kDa	No	0
FDPS-201 ENSP00000483188 ENST00000611010	A0A087X090 [Direct mapping] Farnesyl diphosphate synthase (Farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase), isoform CRA_a; Farnesyl pyrophosphate synthase Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008299 [isoprenoid biosynthetic process] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] Show all	248 aa 28.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.