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CCR5

GENERAL INFORMATION

Gene name

 CCR5

Gene description

 Chemokine (C-C motif) receptor 5 (gene/pseudogene)

Protein class

 CD markers
Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (spleen)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 CCR5 (HGNC Symbol)

Synonyms

 CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22

Description

 Chemokine (C-C motif) receptor 5 (gene/pseudogene) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46370854 - 46376206

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160791 (version 83.38)

Entrez gene

 1234

UniProt

 P51681 (UniProt - Evidence at protein level)

neXtProt

 NX_P51681

Antibodypedia

 CCR5 antibodies

PROTEIN BROWSER
CCR5-001
CCR5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCR5-001
ENSP00000292303
ENST00000292303
P51681 [Direct mapping]
C-C chemokine receptor type 5
Q38L21 [Target identity:100%; Query identity:100%]
C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A variant; C-C motif chemokine receptor 5 I124I variant; C-C motif chemokine receptor 5 I237I variant; CC chemokine receptor 5; Chemokine (C-C motif) receptor 5, isoform CRA_a; cDNA FLJ78003, highly similar to Homo sapiens chemokine (C-C motif) receptor 5, mRNA
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000165 [MAPK cascade]
GO:0001618 [virus receptor activity]
GO:0002407 [dendritic cell chemotaxis]
GO:0003779 [actin binding]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016493 [C-C chemokine receptor activity]
GO:0019722 [calcium-mediated signaling]
GO:0019957 [C-C chemokine binding]
GO:0023052 [signaling]
GO:0030260 [entry into host cell]
GO:0046718 [viral entry into host cell]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070723 [response to cholesterol]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071791 [chemokine (C-C motif) ligand 5 binding]
Show all
 352 aa
40.5 kDa 		No 7
CCR5-003
ENSP00000404881
ENST00000445772
P51681 [Direct mapping]
C-C chemokine receptor type 5
Q38L21 [Target identity:100%; Query identity:100%]
C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A variant; C-C motif chemokine receptor 5 I124I variant; C-C motif chemokine receptor 5 I237I variant; CC chemokine receptor 5; Chemokine (C-C motif) receptor 5, isoform CRA_a; cDNA FLJ78003, highly similar to Homo sapiens chemokine (C-C motif) receptor 5, mRNA
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000165 [MAPK cascade]
GO:0001618 [virus receptor activity]
GO:0002407 [dendritic cell chemotaxis]
GO:0003779 [actin binding]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016493 [C-C chemokine receptor activity]
GO:0019722 [calcium-mediated signaling]
GO:0019957 [C-C chemokine binding]
GO:0023052 [signaling]
GO:0030260 [entry into host cell]
GO:0046718 [viral entry into host cell]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070723 [response to cholesterol]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071791 [chemokine (C-C motif) ligand 5 binding]
Show all
 352 aa
40.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.