Expression of CCDC12 in cancer - Summary - The Human Protein Atlas

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CCDC12

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC12
Gene description	Coiled-coil domain containing 12
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA056814
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056814

GENE INFORMATION
Gene name	CCDC12 (HGNC Symbol)
Synonyms	MGC23918
Description	Coiled-coil domain containing 12 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	46921726 - 46982010
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160799 (version 83.38)
Entrez gene	151903
UniProt	Q8WUD4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WUD4
Antibodypedia	CCDC12 antibodies

PROTEIN BROWSER

CCDC12-001	CCDC12-006	CCDC12-011	CCDC12-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC12-001 ENSP00000416263 ENST00000425441	Q8WUD4 [Direct mapping] Coiled-coil domain-containing protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	166 aa 19.2 kDa	No	0
CCDC12-006 ENSP00000387490 ENST00000446836	C9JUN5 [Direct mapping] Coiled-coil domain-containing protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10.5 kDa	No	0
CCDC12-011 ENSP00000473887 ENST00000605875	S4R331 [Direct mapping] Coiled-coil domain-containing protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 9.6 kDa	No	0
CCDC12-201 ENSP00000292314 ENST00000292314	J3KR35 [Direct mapping] Coiled-coil domain containing 12, isoform CRA_a; Coiled-coil domain-containing protein 12 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		179 aa 20.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.