Expression of PTH1R in cancer - Summary

GENERAL INFORMATION
Gene name	PTH1R
Gene description	Parathyroid hormone 1 receptor
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enriched (RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in selected tissues at variable levels, including subsets of cells in kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA007978
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA007978

GENE INFORMATION
Gene name	PTH1R (HGNC Symbol)
Synonyms	PTHR, PTHR1
Description	Parathyroid hormone 1 receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	46877746 - 46903799
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160801 (version 83.38)
Entrez gene	5745
UniProt	Q03431 (UniProt - Evidence at protein level)
neXtProt	NX_Q03431
Antibodypedia	PTH1R antibodies

PROTEIN BROWSER

PTH1R-001	PTH1R-002	PTH1R-003	PTH1R-004	PTH1R-008	PTH1R-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTH1R-001 ENSP00000321999 ENST00000313049	Q03431 [Direct mapping] Parathyroid hormone/parathyroid hormone-related peptide receptor A0A024R2Z8 [Target identity:100%; Query identity:100%] Parathyroid hormone receptor 1, isoform CRA_a Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0001501 [skeletal system development] GO:0001503 [ossification] GO:0002062 [chondrocyte differentiation] GO:0002076 [osteoblast development] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004991 [parathyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006874 [cellular calcium ion homeostasis] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007568 [aging] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0017046 [peptide hormone binding] GO:0030282 [bone mineralization] GO:0031526 [brush border membrane] GO:0043235 [receptor complex] GO:0043621 [protein self-association] GO:0045453 [bone resorption] GO:0048469 [cell maturation] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070062 [extracellular exosome] Show all	593 aa 66.4 kDa	Yes	7
PTH1R-002 ENSP00000402723 ENST00000449590	Q03431 [Direct mapping] Parathyroid hormone/parathyroid hormone-related peptide receptor A0A024R2Z8 [Target identity:100%; Query identity:100%] Parathyroid hormone receptor 1, isoform CRA_a Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0001501 [skeletal system development] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004991 [parathyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0017046 [peptide hormone binding] GO:0043235 [receptor complex] GO:0043621 [protein self-association] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070062 [extracellular exosome] Show all	593 aa 66.4 kDa	Yes	7
PTH1R-003 ENSP00000411424 ENST00000418619	Q03431 [Direct mapping] Parathyroid hormone/parathyroid hormone-related peptide receptor A0A024R2Z8 [Target identity:100%; Query identity:100%] Parathyroid hormone receptor 1, isoform CRA_a Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0001501 [skeletal system development] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004991 [parathyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0017046 [peptide hormone binding] GO:0043235 [receptor complex] GO:0043621 [protein self-association] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070062 [extracellular exosome] Show all	593 aa 66.4 kDa	Yes	7
PTH1R-004 ENSP00000400977 ENST00000427125	E7EWE7 [Direct mapping] Parathyroid hormone/parathyroid hormone-related peptide receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004991 [parathyroid hormone receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	527 aa 59.5 kDa	Yes	7
PTH1R-008 ENSP00000396176 ENST00000422115	H7C0Q3 [Direct mapping] Parathyroid hormone/parathyroid hormone-related peptide receptor Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004991 [parathyroid hormone receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] Show all	182 aa 20 kDa	No	0
PTH1R-201 ENSP00000413774 ENST00000430002	Q03431 [Direct mapping] Parathyroid hormone/parathyroid hormone-related peptide receptor A0A024R2Z8 [Target identity:100%; Query identity:100%] Parathyroid hormone receptor 1, isoform CRA_a Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0001501 [skeletal system development] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004991 [parathyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0017046 [peptide hormone binding] GO:0043235 [receptor complex] GO:0043621 [protein self-association] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070062 [extracellular exosome] Show all	593 aa 66.4 kDa	Yes	7