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Strong cytoplasmic and membranous staining in most urothelial, breast and pancreatic cancers. A few cases of most other malignancies showed weak to moderate staining.
GENE INFORMATION
Gene name
PTH1R (HGNC Symbol)
Synonyms
PTHR, PTHR1
Description
Parathyroid hormone 1 receptor (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]