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MYL3

GENERAL INFORMATION

Gene name

 MYL3

Gene description

 Myosin, light chain 3, alkali; ventricular, skeletal, slow

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Group enriched (CACO-2, RPTEC TERT1)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA016564 , HPA046859 , HPA063034 , CAB018662
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016564
HPA046859
HPA063034
CAB018662

GENE INFORMATION

Gene name

 MYL3 (HGNC Symbol)

Synonyms

 CMH8, MLC1SB, MLC1V, VLC1

Description

 Myosin, light chain 3, alkali; ventricular, skeletal, slow (HGNC Symbol)

Entrez gene summary

 MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46857872 - 46882169

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160808 (version 83.38)

Entrez gene

 4634

UniProt

 P08590 (UniProt - Evidence at protein level)

neXtProt

 NX_P08590

Antibodypedia

 MYL3 antibodies

PROTEIN BROWSER
MYL3-001
MYL3-002
MYL3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYL3-001
ENSP00000292327
ENST00000292327
P08590 [Direct mapping]
Myosin light chain 3
A0A024R2Q5 [Target identity:100%; Query identity:100%]
Myosin, light polypeptide 3, alkali ventricular, skeletal, slow, isoform CRA_a
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002026 [regulation of the force of heart contraction]
GO:0003785 [actin monomer binding]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006942 [regulation of striated muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0031672 [A band]
GO:0031674 [I band]
GO:0032038 [myosin II heavy chain binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
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 195 aa
21.9 kDa 		No 0
MYL3-002
ENSP00000379210
ENST00000395869
P08590 [Direct mapping]
Myosin light chain 3
A0A024R2Q5 [Target identity:100%; Query identity:100%]
Myosin, light polypeptide 3, alkali ventricular, skeletal, slow, isoform CRA_a
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0003774 [motor activity]
GO:0003785 [actin monomer binding]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006942 [regulation of striated muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0008307 [structural constituent of muscle]
GO:0016459 [myosin complex]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0031672 [A band]
GO:0031674 [I band]
GO:0032038 [myosin II heavy chain binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
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 195 aa
21.9 kDa 		No 0
MYL3-003
ENSP00000393455
ENST00000431168
E9PGV7 [Direct mapping]
Myosin light chain 3
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 46 aa
5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.