Cell atlas - FGFR4 - The Human Protein Atlas

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FGFR4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FGFR4
Gene description	Fibroblast growth factor receptor 4
Protein class	Cancer-related genes CD markers Enzymes FDA approved drug targets Plasma proteins Predicted membrane proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (RH-30, CACO-2, Hep G2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, CACO-2, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FGFR4 (HGNC Symbol)
Synonyms	CD334, JTK2
Description	Fibroblast growth factor receptor 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	177086886 - 177098144
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160867 (version 83.38)
Entrez gene	2264
UniProt	P22455 (UniProt - Evidence at protein level)
neXtProt	NX_P22455
Antibodypedia	FGFR4 antibodies

PROTEIN BROWSER

FGFR4-001	FGFR4-002	FGFR4-003	FGFR4-004	FGFR4-008	FGFR4-009	FGFR4-010	FGFR4-012	FGFR4-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FGFR4-001 ENSP00000292408 ENST00000292408	P22455 [Direct mapping] Fibroblast growth factor receptor 4 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010628 [positive regulation of gene expression] GO:0010715 [regulation of extracellular matrix disassembly] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019216 [regulation of lipid metabolic process] GO:0030133 [transport vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0045087 [innate immune response] GO:0045862 [positive regulation of proteolysis] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048554 [positive regulation of metalloenzyme activity] GO:0055062 [phosphate ion homeostasis] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070857 [regulation of bile acid biosynthetic process] GO:2000188 [regulation of cholesterol homeostasis] GO:2000573 [positive regulation of DNA biosynthetic process] Show all	802 aa 88 kDa	Yes	1
FGFR4-002 ENSP00000377254 ENST00000393637	P22455 [Direct mapping] Fibroblast growth factor receptor 4 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010628 [positive regulation of gene expression] GO:0010715 [regulation of extracellular matrix disassembly] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019216 [regulation of lipid metabolic process] GO:0030133 [transport vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0045087 [innate immune response] GO:0045862 [positive regulation of proteolysis] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048554 [positive regulation of metalloenzyme activity] GO:0055062 [phosphate ion homeostasis] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070857 [regulation of bile acid biosynthetic process] GO:2000188 [regulation of cholesterol homeostasis] GO:2000573 [positive regulation of DNA biosynthetic process] Show all	762 aa 83.5 kDa	Yes	0
FGFR4-003 ENSP00000377259 ENST00000393648	J3KPQ0 [Direct mapping] Receptor protein-tyrosine kinase Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	734 aa 80.5 kDa	Yes	0
FGFR4-004 ENSP00000424960 ENST00000502906	P22455 [Direct mapping] Fibroblast growth factor receptor 4 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010628 [positive regulation of gene expression] GO:0010715 [regulation of extracellular matrix disassembly] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019216 [regulation of lipid metabolic process] GO:0030133 [transport vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0045087 [innate immune response] GO:0045862 [positive regulation of proteolysis] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048554 [positive regulation of metalloenzyme activity] GO:0055062 [phosphate ion homeostasis] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070857 [regulation of bile acid biosynthetic process] GO:2000188 [regulation of cholesterol homeostasis] GO:2000573 [positive regulation of DNA biosynthetic process] Show all	802 aa 88 kDa	Yes	1
FGFR4-008 ENSP00000422889 ENST00000513166	D6R9V0 [Direct mapping] Fibroblast growth factor receptor 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	108 aa 11.8 kDa	Yes	0
FGFR4-009 ENSP00000427222 ENST00000510911	D6RJD4 [Direct mapping] Fibroblast growth factor receptor 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	87 aa 9.5 kDa	Yes	0
FGFR4-010 ENSP00000424905 ENST00000503708	E7EWF4 [Direct mapping] Fibroblast growth factor receptor 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	201 aa 22.2 kDa	Yes	0
FGFR4-012 ENSP00000426492 ENST00000514472	D6RG06 [Direct mapping] Fibroblast growth factor receptor 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	114 aa 12.4 kDa	Yes	0
FGFR4-014 ENSP00000424670 ENST00000511076	H0Y9P2 [Direct mapping] Fibroblast growth factor receptor 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	280 aa 30.3 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.