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CYP3A4

GENERAL INFORMATION

Gene name

 CYP3A4

Gene description

 Cytochrome P450, family 3, subfamily A, polypeptide 4

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, liver, small intestine)
GTEx:Group enriched (liver, small intestine)
FANTOM5:Group enriched (colon, liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in liver, small intestine and duodenum.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB033671
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, liver, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, liver, small intestine)

GENE INFORMATION

Gene name

 CYP3A4 (HGNC Symbol)

Synonyms

 CYP3A3

Description

 Cytochrome P450, family 3, subfamily A, polypeptide 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 99756960 - 99784265

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160868 (version 83.38)

Entrez gene

 1576

UniProt

 P08684 (UniProt - Evidence at protein level)

neXtProt

 NX_P08684

Antibodypedia

 CYP3A4 antibodies

PROTEIN BROWSER
CYP3A4-001
CYP3A4-003
CYP3A4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP3A4-001
ENSP00000337915
ENST00000336411
P08684 [Direct mapping]
Cytochrome P450 3A4
Q6GRK0 [Target identity:100%; Query identity:100%]
Cytochrome P450 family 3 subfamily A polypeptide 4; Cytochrome P450, family 3, subfamily A, polypeptide 4; Cytochrome P450, family 3, subfamily A, polypeptide 4, isoform CRA_a; Cytochrome P450, subfamily IIIA, polypeptide 4; cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNA
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005496 [steroid binding]
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006706 [steroid catabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008202 [steroid metabolic process]
GO:0008209 [androgen metabolic process]
GO:0008395 [steroid hydroxylase activity]
GO:0009822 [alkaloid catabolic process]
GO:0016021 [integral component of membrane]
GO:0016098 [monoterpenoid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0017144 [drug metabolic process]
GO:0019825 [oxygen binding]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0030343 [vitamin D3 25-hydroxylase activity]
GO:0033780 [taurochenodeoxycholate 6alpha-hydroxylase activity]
GO:0034875 [caffeine oxidase activity]
GO:0036378 [calcitriol biosynthetic process from calciol]
GO:0042359 [vitamin D metabolic process]
GO:0042737 [drug catabolic process]
GO:0042738 [exogenous drug catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046483 [heterocycle metabolic process]
GO:0047638 [albendazole monooxygenase activity]
GO:0050591 [quinine 3-monooxygenase activity]
GO:0050649 [testosterone 6-beta-hydroxylase activity]
GO:0055114 [oxidation-reduction process]
GO:0070330 [aromatase activity]
GO:0070576 [vitamin D 24-hydroxylase activity]
GO:0070989 [oxidative demethylation]
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 503 aa
57.3 kDa 		No 0
CYP3A4-003
ENSP00000397208
ENST00000415003
C9JBD2 [Direct mapping]
Cytochrome P450 3A4
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
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 153 aa
17.3 kDa 		No 0
CYP3A4-201
ENSP00000346607
ENST00000354593
E7EVM8 [Direct mapping]
Cytochrome P450 3A4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016021 [integral component of membrane]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
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 353 aa
40.4 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.