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CYP11B1

GENERAL INFORMATION

Gene name

 CYP11B1

Gene description

 Cytochrome P450, family 11, subfamily B, polypeptide 1

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective granular cytoplasmic expression in adrenal gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA049171 , HPA056348 , HPA057752
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049171
HPA056348
HPA057752

GENE INFORMATION

Gene name

 CYP11B1 (HGNC Symbol)

Synonyms

 CPN1, CYP11B, FHI, P450C11

Description

 Cytochrome P450, family 11, subfamily B, polypeptide 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 142872356 - 142879846

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160882 (version 83.38)

Entrez gene

 1584

UniProt

 P15538 (UniProt - Evidence at protein level)

neXtProt

 NX_P15538

Antibodypedia

 CYP11B1 antibodies

PROTEIN BROWSER
CYP11B1-001
CYP11B1-002
CYP11B1-003
CYP11B1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP11B1-001
ENSP00000292427
ENST00000292427
P15538 [Direct mapping]
Cytochrome P450 11B1, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0004507 [steroid 11-beta-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006955 [immune response]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008217 [regulation of blood pressure]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0020037 [heme binding]
GO:0032342 [aldosterone biosynthetic process]
GO:0032870 [cellular response to hormone stimulus]
GO:0034651 [cortisol biosynthetic process]
GO:0035865 [cellular response to potassium ion]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0044550 [secondary metabolite biosynthetic process]
GO:0047783 [corticosterone 18-monooxygenase activity]
GO:0055114 [oxidation-reduction process]
GO:0071375 [cellular response to peptide hormone stimulus]
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 503 aa
57.6 kDa 		No 0
CYP11B1-002
ENSP00000428043
ENST00000517471
P15538 [Direct mapping]
Cytochrome P450 11B1, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004507 [steroid 11-beta-monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006955 [immune response]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008217 [regulation of blood pressure]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0020037 [heme binding]
GO:0032342 [aldosterone biosynthetic process]
GO:0032870 [cellular response to hormone stimulus]
GO:0034651 [cortisol biosynthetic process]
GO:0035865 [cellular response to potassium ion]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0044550 [secondary metabolite biosynthetic process]
GO:0047783 [corticosterone 18-monooxygenase activity]
GO:0055114 [oxidation-reduction process]
GO:0071375 [cellular response to peptide hormone stimulus]
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 437 aa
49.7 kDa 		No 0
CYP11B1-003
ENSP00000366903
ENST00000377675
Q4VAR0 [Direct mapping]
CYP11B1 protein; Cytochrome P450 11B1, mitochondrial
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
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 574 aa
65.1 kDa 		No 0
CYP11B1-005
ENSP00000430144
ENST00000519285
H0YBR4 [Direct mapping]
Cytochrome P450 11B1, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 181 aa
20.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.