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VPS28

GENERAL INFORMATION

Gene name

 VPS28

Gene description

 Vacuolar protein sorting 28 homolog (S. cerevisiae)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA024688 , HPA024745
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024688
HPA024745

GENE INFORMATION

Gene name

 VPS28

Synonyms

Description

 Vacuolar protein sorting 28 homolog (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 144423601 - 144428563

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160948 (version 83.38)

Entrez gene

 51160

UniProt

 Q9UK41 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UK41

Antibodypedia

 VPS28 antibodies

PROTEIN BROWSER
VPS28-002
VPS28-003
VPS28-011
VPS28-012
VPS28-014
VPS28-201
VPS28-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS28-002
ENSP00000434556
ENST00000529182
Q9UK41 [Direct mapping]
Vacuolar protein sorting-associated protein 28 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0010008 [endosome membrane]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031902 [late endosome membrane]
GO:0032403 [protein complex binding]
GO:0043130 [ubiquitin binding]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045732 [positive regulation of protein catabolic process]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
GO:2000397 [positive regulation of ubiquitin-dependent endocytosis]
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 233 aa
26.5 kDa 		No 0
VPS28-003
ENSP00000434064
ENST00000526054
Q9UK41 [Direct mapping]
Vacuolar protein sorting-associated protein 28 homolog
Q548N1 [Target identity:100%; Query identity:100%]
Vacuolar protein sorting 28 (Yeast), isoform CRA_a; Vacuolar sorting protein 28
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0010008 [endosome membrane]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031902 [late endosome membrane]
GO:0032403 [protein complex binding]
GO:0043130 [ubiquitin binding]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045732 [positive regulation of protein catabolic process]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
GO:2000397 [positive regulation of ubiquitin-dependent endocytosis]
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 221 aa
25.4 kDa 		No 0
VPS28-011
ENSP00000431243
ENST00000533806
E9PM90 [Direct mapping]
Vacuolar protein sorting-associated protein 28 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0032403 [protein complex binding]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
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 185 aa
21.2 kDa 		No 0
VPS28-012
ENSP00000434393
ENST00000531032
E9PQR7 [Direct mapping]
Vacuolar protein sorting-associated protein 28 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0032403 [protein complex binding]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
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 161 aa
18.5 kDa 		No 0
VPS28-014
ENSP00000432395
ENST00000530790
E9PR04 [Direct mapping]
Vacuolar protein sorting-associated protein 28 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0032403 [protein complex binding]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
Show all
 53 aa
6 kDa 		No 0
VPS28-201
ENSP00000292510
ENST00000292510
Q9UK41 [Direct mapping]
Vacuolar protein sorting-associated protein 28 homolog
Q548N1 [Target identity:100%; Query identity:100%]
Vacuolar protein sorting 28 (Yeast), isoform CRA_a; Vacuolar sorting protein 28
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0010008 [endosome membrane]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031902 [late endosome membrane]
GO:0032403 [protein complex binding]
GO:0043130 [ubiquitin binding]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045732 [positive regulation of protein catabolic process]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
GO:2000397 [positive regulation of ubiquitin-dependent endocytosis]
Show all
 221 aa
25.4 kDa 		No 0
VPS28-202
ENSP00000366565
ENST00000377348
Q9UK41 [Direct mapping]
Vacuolar protein sorting-associated protein 28 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000813 [ESCRT I complex]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0010008 [endosome membrane]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031902 [late endosome membrane]
GO:0032403 [protein complex binding]
GO:0043130 [ubiquitin binding]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045732 [positive regulation of protein catabolic process]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0075733 [intracellular transport of virus]
GO:2000397 [positive regulation of ubiquitin-dependent endocytosis]
Show all
 233 aa
26.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.