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PTGER1

GENERAL INFORMATION

Gene name

 PTGER1

Gene description

 Prostaglandin E receptor 1 (subtype EP1), 42kDa

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (ovarian cancer)
HPA (cell line):Cell line enhanced (HEL, PC-3, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (kidney, spleen)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PTGER1 (HGNC Symbol)

Synonyms

 EP1

Description

 Prostaglandin E receptor 1 (subtype EP1), 42kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 14472466 - 14475362

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000160951 (version 83.38)

Entrez gene

 5731

UniProt

 P34995 (UniProt - Evidence at transcript level)

neXtProt

 NX_P34995

Antibodypedia

 PTGER1 antibodies

PROTEIN BROWSER
PTGER1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGER1-001
ENSP00000292513
ENST00000292513
P34995 [Direct mapping]
Prostaglandin E2 receptor EP1 subtype
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0032496 [response to lipopolysaccharide]
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 402 aa
41.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.