Expression of MUM1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MUM1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MUM1
Gene description	Melanoma associated antigen (mutated) 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA048063
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and endometrial cancer (favourable).
Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048063

GENE INFORMATION
Gene name	MUM1 (HGNC Symbol)
Synonyms	EXPAND1, MUM-1
Description	Melanoma associated antigen (mutated) 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1285893 - 1378431
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160953 (version 83.38)
Entrez gene	84939
UniProt	Q2TAK8 (UniProt - Evidence at protein level)
neXtProt	NX_Q2TAK8
Antibodypedia	MUM1 antibodies

PROTEIN BROWSER

MUM1-001	MUM1-007	MUM1-009	MUM1-014	MUM1-201	MUM1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MUM1-001 ENSP00000467083 ENST00000591806	J3KNX4 [Direct mapping] PWWP domain-containing protein MUM1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		711 aa 78.8 kDa	No	0
MUM1-007 ENSP00000466891 ENST00000592374	K7END0 [Direct mapping] PWWP domain-containing protein MUM1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		48 aa 5.7 kDa	No	0
MUM1-009 ENSP00000467287 ENST00000591337	K7EP97 [Direct mapping] PWWP domain-containing protein MUM1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		264 aa 28.8 kDa	No	0
MUM1-014 ENSP00000394925 ENST00000415183	Q2TAK8 [Direct mapping] PWWP domain-containing protein MUM1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0006325 [chromatin organization] GO:0031491 [nucleosome binding] Show all	732 aa 80.8 kDa	No	0
MUM1-201 ENSP00000486562 ENST00000626522	J3KNX4 [Direct mapping] PWWP domain-containing protein MUM1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		711 aa 78.8 kDa	No	0
MUM1-202 ENSP00000487567 ENST00000627377	A0A0D9SGJ8 [Direct mapping] PWWP domain-containing protein MUM1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		732 aa 80.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.