Expression of LRRC14 in cancer - Summary - The Human Protein Atlas

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LRRC14

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRC14
Gene description	Leucine rich repeat containing 14
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA021047
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021047

GENE INFORMATION
Gene name	LRRC14 (HGNC Symbol)
Synonyms	KIAA0014, LRRC14A
Description	Leucine rich repeat containing 14 (HGNC Symbol)
Entrez gene summary	This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144517992 - 144525178
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160959 (version 83.38)
Entrez gene	9684
UniProt	Q15048 (UniProt - Evidence at transcript level)
neXtProt	NX_Q15048
Antibodypedia	LRRC14 antibodies

PROTEIN BROWSER

LRRC14-001	LRRC14-002	LRRC14-003	LRRC14-004	LRRC14-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC14-001 ENSP00000292524 ENST00000292524	Q15048 [Direct mapping] Leucine-rich repeat-containing protein 14 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		493 aa 54.5 kDa	No	0
LRRC14-002 ENSP00000434768 ENST00000529022	Q15048 [Direct mapping] Leucine-rich repeat-containing protein 14 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		493 aa 54.5 kDa	No	0
LRRC14-003 ENSP00000436452 ENST00000527730	E9PP40 [Direct mapping] Leucine-rich repeat-containing protein 14 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		301 aa 33.5 kDa	No	0
LRRC14-004 ENSP00000435985 ENST00000530854	E9PRP5 [Direct mapping] Leucine-rich repeat-containing protein 14 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 10 kDa	No	0
LRRC14-005 ENSP00000434738 ENST00000525766	E9PNL0 [Direct mapping] Leucine-rich repeat-containing protein 14 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 17.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.