Expression of ORAI2 in cancer - Summary - The Human Protein Atlas

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ORAI2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ORAI2
Gene description	ORAI calcium release-activated calcium modulator 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA065937
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and thyroid cancer (favourable).
Pancreatic cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065937

GENE INFORMATION
Gene name	ORAI2 (HGNC Symbol)
Synonyms	C7orf19, CBCIP2, FLJ12474, FLJ14733, H_NH0514P08.8, TMEM142B
Description	ORAI calcium release-activated calcium modulator 2 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	102433106 - 102456821
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160991 (version 83.38)
Entrez gene	80228
UniProt	Q96SN7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96SN7
Antibodypedia	ORAI2 antibodies

PROTEIN BROWSER

ORAI2-001	ORAI2-002	ORAI2-003	ORAI2-004	ORAI2-005	ORAI2-006	ORAI2-008	ORAI2-201	ORAI2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ORAI2-001 ENSP00000418140 ENST00000478730	Q96SN7 [Direct mapping] Protein orai-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0002115 [store-operated calcium entry] GO:0005515 [protein binding] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	254 aa 28.6 kDa	No	4
ORAI2-002 ENSP00000385489 ENST00000403646	Q96SN7 [Direct mapping] Protein orai-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0002115 [store-operated calcium entry] GO:0005515 [protein binding] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	254 aa 28.6 kDa	No	4
ORAI2-003 ENSP00000417928 ENST00000473939	Q96SN7 [Direct mapping] Protein orai-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0002115 [store-operated calcium entry] GO:0005515 [protein binding] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	254 aa 28.6 kDa	No	4
ORAI2-004 ENSP00000420178 ENST00000495936	C9JQR7 [Direct mapping] Protein orai-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0002115 [store-operated calcium entry] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	229 aa 25.6 kDa	No	4
ORAI2-005 ENSP00000418464 ENST00000498661	C9J5L2 [Direct mapping] Protein orai-2 Show all	Predicted intracellular proteins Show all	GO:0002115 [store-operated calcium entry] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	97 aa 11 kDa	No	0
ORAI2-006 ENSP00000419416 ENST00000482237	C9JUY6 [Direct mapping] Protein orai-2 Show all	Predicted intracellular proteins Show all	GO:0002115 [store-operated calcium entry] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	30 aa 3.3 kDa	No	0
ORAI2-008 ENSP00000417407 ENST00000468241	C9J2H9 [Direct mapping] Protein orai-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0002115 [store-operated calcium entry] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	212 aa 23.4 kDa	No	3
ORAI2-201 ENSP00000348752 ENST00000356387	Q96SN7 [Direct mapping] Protein orai-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0002115 [store-operated calcium entry] GO:0005515 [protein binding] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030426 [growth cone] GO:0070588 [calcium ion transmembrane transport] Show all	254 aa 28.6 kDa	No	4
ORAI2-202 ENSP00000478113 ENST00000611770	Q96SN7 [Direct mapping] Protein orai-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0002115 [store-operated calcium entry] GO:0005515 [protein binding] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	254 aa 28.6 kDa	No	4

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The Human Protein Atlas

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