Expression of MFSD12 in cancer - Summary - The Human Protein Atlas

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MFSD12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MFSD12
Gene description	Major facilitator superfamily domain containing 12
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA042149 , HPA043088
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), lung cancer (unfavourable), liver cancer (unfavourable) and stomach cancer (favourable).
Endometrial cancer p<0.001 Lung cancer p<0.001 Liver cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042149	HPA043088

GENE INFORMATION
Gene name	MFSD12 (HGNC Symbol)
Synonyms	C19orf28, MGC20700, PP3501
Description	Major facilitator superfamily domain containing 12 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	3538261 - 3574290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161091 (version 83.38)
Entrez gene	126321
UniProt	Q6NUT3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NUT3
Antibodypedia	MFSD12 antibodies

PROTEIN BROWSER

MFSD12-001	MFSD12-005	MFSD12-006	MFSD12-007	MFSD12-008	MFSD12-011	MFSD12-201	MFSD12-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFSD12-001 ENSP00000347583 ENST00000355415	Q6NUT3 [Direct mapping] Major facilitator superfamily domain-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	480 aa 52.1 kDa	No	>9
MFSD12-005 ENSP00000478456 ENST00000615073	A0A087WU85 [Direct mapping] Major facilitator superfamily domain-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	163 aa 17.1 kDa	No	2
MFSD12-006 ENSP00000465302 ENST00000589995	K7EJS5 [Direct mapping] Major facilitator superfamily domain-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	259 aa 28.5 kDa	No	5
MFSD12-007 ENSP00000467635 ENST00000589063	K7EQ22 [Direct mapping] Major facilitator superfamily domain-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	180 aa 18.9 kDa	No	1
MFSD12-008 ENSP00000466906 ENST00000592652	K7ENE1 [Direct mapping] Major facilitator superfamily domain-containing protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		147 aa 15 kDa	No	0
MFSD12-011 ENSP00000381566 ENST00000398558	A0A0A0MS91 [Direct mapping] Major facilitator superfamily domain-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	175 aa 18.7 kDa	No	2
MFSD12-201 ENSP00000374046 ENST00000389395	Q6NUT3 [Direct mapping] Major facilitator superfamily domain-containing protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	471 aa 51 kDa	No	>9
MFSD12-202 ENSP00000481557 ENST00000615613	Q9HBP8 [Direct mapping] Chromosome 19 open reading frame 28, isoform CRA_b; Major facilitator superfamily domain-containing protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 15.7 kDa	No	0

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The Human Protein Atlas

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