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AP2M1

GENERAL INFORMATION

Gene name

 AP2M1

Gene description

 Adaptor-related protein complex 2, mu 1 subunit

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA036849
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036849

GENE INFORMATION

Gene name

 AP2M1 (HGNC Symbol)

Synonyms

 AP50, CLAPM1, mu2

Description

 Adaptor-related protein complex 2, mu 1 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Chromosome

 3

Cytoband

 q27.1

Chromosome location (bp)

 184174689 - 184184091

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161203 (version 83.38)

Entrez gene

 1173

UniProt

 Q96CW1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96CW1

Antibodypedia

 AP2M1 antibodies

PROTEIN BROWSER
«
AP2M1-001
AP2M1-002
AP2M1-003
AP2M1-005
AP2M1-009
AP2M1-011
AP2M1-014
AP2M1-015
AP2M1-017
AP2M1-022
AP2M1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP2M1-001
ENSP00000371894
ENST00000382456
Q96CW1 [Direct mapping]
AP-2 complex subunit mu
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005048 [signal sequence binding]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008289 [lipid binding]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030122 [AP-2 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
GO:1903077 [negative regulation of protein localization to plasma membrane]
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 433 aa
49.4 kDa 		No 0
AP2M1-002
ENSP00000403362
ENST00000411763
E9PFW3 [Direct mapping]
AP-2 complex subunit mu
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 460 aa
52.3 kDa 		No 0
AP2M1-003
ENSP00000292807
ENST00000292807
Q96CW1 [Direct mapping]
AP-2 complex subunit mu
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005048 [signal sequence binding]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008289 [lipid binding]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030122 [AP-2 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043195 [terminal bouton]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
GO:1903077 [negative regulation of protein localization to plasma membrane]
Show all
 435 aa
49.7 kDa 		No 0
AP2M1-005
ENSP00000409081
ENST00000439647
Q96CW1 [Direct mapping]
AP-2 complex subunit mu
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005048 [signal sequence binding]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008289 [lipid binding]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030122 [AP-2 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
GO:1903077 [negative regulation of protein localization to plasma membrane]
Show all
 433 aa
49.4 kDa 		No 0
AP2M1-009
ENSP00000402051
ENST00000427072
C9JPV8 [Direct mapping]
AP-2 complex subunit mu
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
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 136 aa
15.4 kDa 		No 0
AP2M1-011
ENSP00000402592
ENST00000448139
C9JTK4 [Direct mapping]
AP-2 complex subunit mu
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 160 aa
18.3 kDa 		No 0
AP2M1-014
ENSP00000404031
ENST00000455925
C9JJD3 [Direct mapping]
AP-2 complex subunit mu
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 113 aa
13 kDa 		No 0
AP2M1-015
ENSP00000395438
ENST00000432591
C9JJ47 [Direct mapping]
AP-2 complex subunit mu
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 252 aa
28.8 kDa 		No 0
AP2M1-017
ENSP00000404326
ENST00000431779
C9JGT8 [Direct mapping]
AP-2 complex subunit mu
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 195 aa
22.2 kDa 		No 0
AP2M1-022
ENSP00000416688
ENST00000442686
H7C4C3 [Direct mapping]
AP-2 complex subunit mu
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 122 aa
14.1 kDa 		No 0
AP2M1-201
ENSP00000481563
ENST00000621863
A0A087WY71 [Direct mapping]
AP-2 complex subunit mu
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
Show all
 434 aa
49.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.