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COX7A1

GENERAL INFORMATION

Gene name

 COX7A1

Gene description

 Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, BJ, BJ hTERT+, EFO-21)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 COX7A1 (HGNC Symbol)

Synonyms

 COX7A, COX7AH

Description

 Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) (HGNC Symbol)

Entrez gene summary

 Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.12

Chromosome location (bp)

 36150922 - 36152869

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161281 (version 83.38)

Entrez gene

 1346

UniProt

 P24310 (UniProt - Evidence at protein level)

neXtProt

 NX_P24310

Antibodypedia

 COX7A1 antibodies

PROTEIN BROWSER
COX7A1-001
COX7A1-003
COX7A1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COX7A1-001
ENSP00000292907
ENST00000292907
P24310 [Direct mapping]
Cytochrome c oxidase subunit 7A1, mitochondrial
Q6FGI7 [Target identity:100%; Query identity:100%]
COX7A1 protein; Cytochrome c oxidase subunit VIIa polypeptide 1 (Muscle); cDNA, FLJ92372, Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 1(muscle) (COX7A1), mRNA
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004129 [cytochrome-c oxidase activity]
GO:0005739 [mitochondrion]
GO:0005746 [mitochondrial respiratory chain]
GO:0006091 [generation of precursor metabolites and energy]
GO:0016021 [integral component of membrane]
GO:1902600 [hydrogen ion transmembrane transport]
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 79 aa
9.1 kDa 		No 1
COX7A1-003
ENSP00000475885
ENST00000437291
U3KQH8 [Direct mapping]
Cytochrome c oxidase subunit 7A1, mitochondrial
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004129 [cytochrome-c oxidase activity]
GO:0005746 [mitochondrial respiratory chain]
GO:1902600 [hydrogen ion transmembrane transport]
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 23 aa
2.5 kDa 		No 0
COX7A1-004
ENSP00000468063
ENST00000589154
K7ER11 [Direct mapping]
Cytochrome c oxidase subunit 7A1, mitochondrial
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004129 [cytochrome-c oxidase activity]
GO:0005746 [mitochondrial respiratory chain]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 61 aa
6.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.