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CYGB

GENERAL INFORMATION

Gene name

 CYGB

Gene description

 Cytoglobin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Hep G2, SH-SY5Y)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in a subset of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA017757
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), glioma (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001
Glioma p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017757

GENE INFORMATION

Gene name

 CYGB (HGNC Symbol)

Synonyms

 HGB, STAP

Description

 Cytoglobin (HGNC Symbol)

Entrez gene summary

 This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 76527356 - 76551175

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161544 (version 83.38)

Entrez gene

 114757

UniProt

 Q8WWM9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WWM9

Antibodypedia

 CYGB antibodies

PROTEIN BROWSER
CYGB-001
CYGB-002
CYGB-003
CYGB-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYGB-001
ENSP00000293230
ENST00000293230
Q8WWM9 [Direct mapping]
Cytoglobin
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0004096 [catalase activity]
GO:0004601 [peroxidase activity]
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006979 [response to oxidative stress]
GO:0008941 [nitric oxide dioxygenase activity]
GO:0010764 [negative regulation of fibroblast migration]
GO:0015671 [oxygen transport]
GO:0019395 [fatty acid oxidation]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0032966 [negative regulation of collagen biosynthetic process]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0044281 [small molecule metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0047888 [fatty acid peroxidase activity]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:2000490 [negative regulation of hepatic stellate cell activation]
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 190 aa
21.4 kDa 		No 0
CYGB-002
ENSP00000466448
ENST00000589342
K7EMC7 [Direct mapping]
Cytoglobin
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
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 226 aa
25 kDa 		No 0
CYGB-003
ENSP00000464817
ENST00000590175
K7EIM9 [Direct mapping]
Cytoglobin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
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 125 aa
13.7 kDa 		No 0
CYGB-005
ENSP00000468559
ENST00000589145
K7EIM9 [Direct mapping]
Cytoglobin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
 125 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.