Expression of DCD in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DCD
Gene description	Dermcidin
Protein class	Plasma proteins Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High expression in the cytoplasm and cell membranes of secretory cells in sweat glands.

ANTIBODY IHC RELIABILITY
Data reliability description	HPA RNA breast sample 2 may contain sweat glands. Antibody staining consistent with GTEx RNA expression data.
Reliability score	Supported based on 1 antibody. HPA063967
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA063967

GENE INFORMATION
Gene name	DCD (HGNC Symbol)
Synonyms	AIDD, DCD-1, DSEP, HCAP, PIF
Description	Dermcidin (HGNC Symbol)
Entrez gene summary	This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Chromosome	12
Cytoband	q13.2
Chromosome location (bp)	54644591 - 54648493
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161634 (version 83.38)
Entrez gene	117159
UniProt	P81605 (UniProt - Evidence at protein level)
neXtProt	NX_P81605
Antibodypedia	DCD antibodies

PROTEIN BROWSER

DCD-001	DCD-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCD-001 ENSP00000293371 ENST00000293371	P81605 [Direct mapping] Dermcidin Survival-promoting peptide DCD-1 Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0031640 [killing of cells of other organism] GO:0042742 [defense response to bacterium] GO:0044822 [poly(A) RNA binding] GO:0050832 [defense response to fungus] GO:0070062 [extracellular exosome] Show all	110 aa 11.3 kDa	Yes	0
DCD-003 ENSP00000406773 ENST00000456047	P81605 [Direct mapping] Dermcidin Survival-promoting peptide DCD-1 Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0031640 [killing of cells of other organism] GO:0042742 [defense response to bacterium] GO:0044822 [poly(A) RNA binding] GO:0050832 [defense response to fungus] GO:0070062 [extracellular exosome] Show all	121 aa 12.4 kDa	Yes	0