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SHANK1

GENERAL INFORMATION

Gene name

 SHANK1

Gene description

 SH3 and multiple ankyrin repeat domains 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (ovarian cancer)
HPA (cell line):Cell line enhanced (REH, U-2 OS)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including including neurons and glial cells of the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA032129 , HPA032130
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA032129
HPA032130

GENE INFORMATION

Gene name

 SHANK1 (HGNC Symbol)

Synonyms

 SPANK-1, SSTRIP, synamon

Description

 SH3 and multiple ankyrin repeat domains 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 50661827 - 50719450

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161681 (version 83.38)

Entrez gene

 50944

UniProt

 Q9Y566 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y566

Antibodypedia

 SHANK1 antibodies

PROTEIN BROWSER
SHANK1-001
SHANK1-002
SHANK1-003
SHANK1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SHANK1-001
ENSP00000293441
ENST00000293441
Q9Y566 [Direct mapping]
SH3 and multiple ankyrin repeat domains protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007616 [long-term memory]
GO:0008022 [protein C-terminus binding]
GO:0008306 [associative learning]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030160 [GKAP/Homer scaffold activity]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031877 [somatostatin receptor binding]
GO:0032232 [negative regulation of actin filament bundle assembly]
GO:0032403 [protein complex binding]
GO:0035176 [social behavior]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0042048 [olfactory behavior]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046959 [habituation]
GO:0050885 [neuromuscular process controlling balance]
GO:0050894 [determination of affect]
GO:0060013 [righting reflex]
GO:0060074 [synapse maturation]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0060999 [positive regulation of dendritic spine development]
GO:0071532 [ankyrin repeat binding]
GO:0071625 [vocalization behavior]
GO:0097110 [scaffold protein binding]
GO:0097481 [neuronal postsynaptic density]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
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 2161 aa
225 kDa 		No 0
SHANK1-002
ENSP00000375690
ENST00000391814
H9KV90 [Direct mapping]
SH3 and multiple ankyrin repeat domains protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 2169 aa
225.9 kDa 		No 0
SHANK1-003
ENSP00000375689
ENST00000391813
Q9Y566 [Direct mapping]
SH3 and multiple ankyrin repeat domains protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007616 [long-term memory]
GO:0008022 [protein C-terminus binding]
GO:0008306 [associative learning]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030160 [GKAP/Homer scaffold activity]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031877 [somatostatin receptor binding]
GO:0032232 [negative regulation of actin filament bundle assembly]
GO:0032403 [protein complex binding]
GO:0035176 [social behavior]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0045211 [postsynaptic membrane]
GO:0050885 [neuromuscular process controlling balance]
GO:0050894 [determination of affect]
GO:0060074 [synapse maturation]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0060999 [positive regulation of dendritic spine development]
GO:0071532 [ankyrin repeat binding]
GO:0071625 [vocalization behavior]
GO:0097110 [scaffold protein binding]
GO:0097481 [neuronal postsynaptic density]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 1548 aa
158.8 kDa 		No 0
SHANK1-008
ENSP00000351984
ENST00000359082
Q9Y566 [Direct mapping]
SH3 and multiple ankyrin repeat domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007616 [long-term memory]
GO:0008022 [protein C-terminus binding]
GO:0008306 [associative learning]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030160 [GKAP/Homer scaffold activity]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031877 [somatostatin receptor binding]
GO:0032232 [negative regulation of actin filament bundle assembly]
GO:0032403 [protein complex binding]
GO:0035176 [social behavior]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035418 [protein localization to synapse]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0045211 [postsynaptic membrane]
GO:0050885 [neuromuscular process controlling balance]
GO:0050894 [determination of affect]
GO:0060074 [synapse maturation]
GO:0060076 [excitatory synapse]
GO:0060997 [dendritic spine morphogenesis]
GO:0060999 [positive regulation of dendritic spine development]
GO:0071532 [ankyrin repeat binding]
GO:0071625 [vocalization behavior]
GO:0097110 [scaffold protein binding]
GO:0097481 [neuronal postsynaptic density]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 2152 aa
224.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.