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PLCD3

GENERAL INFORMATION

Gene name

 PLCD3

Gene description

 Phospholipase C, delta 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA025711
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 PLCD3

Synonyms

Description

 Phospholipase C, delta 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 45108967 - 45133354

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161714 (version 83.38)

Entrez gene

 113026

UniProt

 Q8N3E9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N3E9

Antibodypedia

 PLCD3 antibodies

PROTEIN BROWSER
PLCD3-001
PLCD3-003
PLCD3-011
PLCD3-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCD3-001
ENSP00000479636
ENST00000619929
Q8N3E9 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0032154 [cleavage furrow]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0060716 [labyrinthine layer blood vessel development]
Show all
 789 aa
89.3 kDa 		No 0
PLCD3-003
ENSP00000440378
ENST00000538093
F5GXC1 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005622 [intracellular]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
Show all
 127 aa
15.1 kDa 		No 0
PLCD3-011
ENSP00000443079
ENST00000539433
H0YGF8 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
Show all
 111 aa
12.2 kDa 		No 0
PLCD3-013
ENSP00000467800
ENST00000590644
K7EQF2 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005622 [intracellular]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
Show all
 195 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.