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KRT84

GENERAL INFORMATION

Gene name

 KRT84

Gene description

 Keratin 84, type II

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in subset of cells in external root sheath of hair follicle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Antibody staining partly consistent with external characterization data.

Reliability score

 Supported based on 1 antibody.
HPA039714
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039714

GENE INFORMATION

Gene name

 KRT84 (HGNC Symbol)

Synonyms

 Hb-4, KRTHB4

Description

 Keratin 84, type II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52377812 - 52385652

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161849 (version 83.38)

Entrez gene

 3890

UniProt

 Q9NSB2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9NSB2

Antibodypedia

 KRT84 antibodies

PROTEIN BROWSER
KRT84-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT84-001
ENSP00000257951
ENST00000257951
Q9NSB2 [Direct mapping]
Keratin, type II cuticular Hb4
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001942 [hair follicle development]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005882 [intermediate filament]
GO:0030280 [structural constituent of epidermis]
GO:0035878 [nail development]
GO:0045095 [keratin filament]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045616 [regulation of keratinocyte differentiation]
GO:0070062 [extracellular exosome]
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 600 aa
64.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.