Expression of LEMD2 in cancer - Summary - The Human Protein Atlas

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LEMD2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LEMD2
Gene description	LEM domain containing 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA017340
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017340

GENE INFORMATION
Gene name	LEMD2 (HGNC Symbol)
Synonyms	dJ482C21.1, NET25
Description	LEM domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	33771202 - 33789136
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161904 (version 83.38)
Entrez gene	221496
UniProt	Q8NC56 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NC56
Antibodypedia	LEMD2 antibodies

PROTEIN BROWSER

LEMD2-001	LEMD2-002	LEMD2-004	LEMD2-005	LEMD2-012	LEMD2-013	LEMD2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LEMD2-001 ENSP00000293760 ENST00000293760	Q8NC56 [Direct mapping] LEM domain-containing protein 2 A0A024RCZ1 [Target identity:100%; Query identity:100%] LEM domain containing 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005639 [integral component of nuclear inner membrane] GO:0006998 [nuclear envelope organization] GO:0016020 [membrane] GO:0022008 [neurogenesis] GO:0031965 [nuclear membrane] GO:0035914 [skeletal muscle cell differentiation] GO:0043409 [negative regulation of MAPK cascade] GO:0051898 [negative regulation of protein kinase B signaling] GO:0060914 [heart formation] Show all	503 aa 57 kDa	No	2
LEMD2-002 ENSP00000408524 ENST00000442696	H7C2Z0 [Direct mapping] LEM domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005639 [integral component of nuclear inner membrane] GO:0016021 [integral component of membrane] Show all	280 aa 30.7 kDa	No	2
LEMD2-004 ENSP00000421704 ENST00000508327	Q8NC56 [Direct mapping] LEM domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005639 [integral component of nuclear inner membrane] GO:0006998 [nuclear envelope organization] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0035914 [skeletal muscle cell differentiation] Show all	201 aa 23.5 kDa	No	1
LEMD2-005 ENSP00000423619 ENST00000513701	D6R958 [Direct mapping] LEM domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 5.9 kDa	No	0
LEMD2-012 ENSP00000421112 ENST00000504692	H0Y8H8 [Direct mapping] LEM domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005639 [integral component of nuclear inner membrane] Show all	102 aa 12 kDa	No	1
LEMD2-013 ENSP00000423715 ENST00000506578	H0Y9B7 [Direct mapping] LEM domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005639 [integral component of nuclear inner membrane] Show all	85 aa 10.2 kDa	No	0
LEMD2-201 ENSP00000478539 ENST00000614475	Q8NC56 [Direct mapping] LEM domain-containing protein 2 A0A024RCZ1 [Target identity:100%; Query identity:100%] LEM domain containing 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005639 [integral component of nuclear inner membrane] GO:0006998 [nuclear envelope organization] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0035914 [skeletal muscle cell differentiation] Show all	503 aa 57 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.