Expression of MED11 in cancer - Summary - The Human Protein Atlas

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MED11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MED11
Gene description	Mediator complex subunit 11
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA056669
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056669

GENE INFORMATION
Gene name	MED11 (HGNC Symbol)
Synonyms	HSPC296, MGC88387
Description	Mediator complex subunit 11 (HGNC Symbol)
Entrez gene summary	MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4731428 - 4733610
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161920 (version 83.38)
Entrez gene	400569
UniProt	Q9P086 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P086
Antibodypedia	MED11 antibodies

PROTEIN BROWSER

MED11-001	MED11-002	MED11-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED11-001 ENSP00000293777 ENST00000293777	Q9P086 [Direct mapping] Mediator of RNA polymerase II transcription subunit 11 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016567 [protein ubiquitination] GO:0016592 [mediator complex] GO:0061630 [ubiquitin protein ligase activity] Show all	117 aa 13.1 kDa	No	0
MED11-002 ENSP00000459834 ENST00000573708	I3L2Q0 [Direct mapping] Mediator of RNA polymerase II transcription subunit 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	93 aa 10.2 kDa	No	0
MED11-003 ENSP00000460400 ENST00000575284	I3L3E8 [Direct mapping] Mediator of RNA polymerase II transcription subunit 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	85 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.