Expression of SCIMP in cancer - Summary - The Human Protein Atlas

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SCIMP

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SCIMP
Gene description	SLP adaptor and CSK interacting membrane protein
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (U-698)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA006117
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006117

GENE INFORMATION
Gene name	SCIMP (HGNC Symbol)
Synonyms	C17orf87, DTFT5783, FLJ32580, MGC163426, MGC163428, UNQ5783
Description	SLP adaptor and CSK interacting membrane protein (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	5208961 - 5234860
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161929 (version 83.38)
Entrez gene	388325
UniProt	Q6UWF3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWF3
Antibodypedia	SCIMP antibodies

PROTEIN BROWSER

SCIMP-001	SCIMP-002	SCIMP-003	SCIMP-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCIMP-001 ENSP00000461269 ENST00000574081	Q6UWF3 [Direct mapping] SLP adapter and CSK-interacting membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001772 [immunological synapse] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031256 [leading edge membrane] GO:0031259 [uropod membrane] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0097197 [tetraspanin-enriched microdomain] Show all	145 aa 16.6 kDa	No	1
SCIMP-002 ENSP00000459605 ENST00000571800	Q6UWF3 [Direct mapping] SLP adapter and CSK-interacting membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001772 [immunological synapse] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031256 [leading edge membrane] GO:0031259 [uropod membrane] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0097197 [tetraspanin-enriched microdomain] Show all	123 aa 13.9 kDa	No	1
SCIMP-003 ENSP00000382509 ENST00000399600	Q6UWF3 [Direct mapping] SLP adapter and CSK-interacting membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001772 [immunological synapse] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031256 [leading edge membrane] GO:0031259 [uropod membrane] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0097197 [tetraspanin-enriched microdomain] Show all	138 aa 15.7 kDa	No	1
SCIMP-004 ENSP00000459153 ENST00000574297	I3L1W2 [Direct mapping] SLP adapter and CSK-interacting membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001772 [immunological synapse] GO:0016021 [integral component of membrane] GO:0097197 [tetraspanin-enriched microdomain] Show all	130 aa 14.9 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.