Expression of BCL6B in cancer - Summary - The Human Protein Atlas

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BCL6B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BCL6B
Gene description	B-cell CLL/lymphoma 6, member B
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (HEL, HMC-1, HUVEC TERT2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA059147
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and renal cancer (unfavourable).
Head and neck cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059147

GENE INFORMATION
Gene name	BCL6B (HGNC Symbol)
Synonyms	BAZF, ZBTB28, ZNF62
Description	B-cell CLL/lymphoma 6, member B (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7023020 - 7030290
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000161940 (version 83.38)
Entrez gene	255877
UniProt	Q8N143 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N143
Antibodypedia	BCL6B antibodies

PROTEIN BROWSER

BCL6B-001	BCL6B-002	BCL6B-005	BCL6B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL6B-001 ENSP00000293805 ENST00000293805	Q8N143 [Direct mapping] B-cell CLL/lymphoma 6 member B protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	479 aa 51.5 kDa	No	0
BCL6B-002 ENSP00000445010 ENST00000537931	H0YGW0 [Direct mapping] B-cell CLL/lymphoma 6 member B protein Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0046872 [metal ion binding] Show all	135 aa 15.3 kDa	No	0
BCL6B-005 ENSP00000460282 ENST00000573503	I3L396 [Direct mapping] B-cell CLL/lymphoma 6 member B protein Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] Show all	111 aa 11.7 kDa	No	0
BCL6B-006 ENSP00000460071 ENST00000576705	I3L304 [Direct mapping] B-cell CLL/lymphoma 6 member B protein Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] Show all	133 aa 14.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.