Expression of SENP3 in cancer - Summary - The Human Protein Atlas

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SENP3

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SENP3
Gene description	SUMO1/sentrin/SMT3 specific peptidase 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA060290
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA060290

GENE INFORMATION
Gene name	SENP3 (HGNC Symbol)
Synonyms	DKFZP586K0919, DKFZp762A152, SMT3IP1, SSP3, Ulp1
Description	SUMO1/sentrin/SMT3 specific peptidase 3 (HGNC Symbol)
Entrez gene summary	The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7561875 - 7571969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161956 (version 83.38)
Entrez gene	26168
UniProt	Q9H4L4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H4L4
Antibodypedia	SENP3 antibodies

PROTEIN BROWSER

SENP3-001	SENP3-005	SENP3-006	SENP3-007	SENP3-008	SENP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SENP3-001 ENSP00000314029 ENST00000321337	Q9H4L4 [Direct mapping] Sentrin-specific protease 3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0016926 [protein desumoylation] GO:0016929 [SUMO-specific protease activity] GO:0071339 [MLL1 complex] Show all	574 aa 65 kDa	No	0
SENP3-005 ENSP00000463358 ENST00000580231	J3QL36 [Direct mapping] Sentrin-specific protease 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	237 aa 27.8 kDa	No	0
SENP3-006 ENSP00000462461 ENST00000581093	J3KSF5 [Direct mapping] Sentrin-specific protease 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	82 aa 9.9 kDa	No	0
SENP3-007 ENSP00000464172 ENST00000582789	J3QRE4 [Direct mapping] Sentrin-specific protease 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	110 aa 13.3 kDa	No	0
SENP3-008 ENSP00000479187 ENST00000610454	A0A087WV50 [Direct mapping] Sentrin-specific protease 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	177 aa 20.5 kDa	No	0
SENP3-201 ENSP00000403712 ENST00000429205	Q9H4L4 [Direct mapping] Sentrin-specific protease 3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0016926 [protein desumoylation] GO:0016929 [SUMO-specific protease activity] GO:0071339 [MLL1 complex] Show all	574 aa 65 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.