Expression of TBC1D24 in cancer - Summary - The Human Protein Atlas

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TBC1D24

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TBC1D24
Gene description	TBC1 domain family, member 24
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, high abundance in several glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044712
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044712

GENE INFORMATION
Gene name	TBC1D24 (HGNC Symbol)
Synonyms	DFNA65, DFNB86, KIAA1171, TLDC6
Description	TBC1 domain family, member 24 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a conserved domain, referred to as the TBC domain, characteristic of proteins which interact with GTPases. TBC domain proteins may serve as GTPase-activating proteins for a particular group of GTPases, the Rab (Ras-related proteins in brain) small GTPases which are involved in the regulation of membrane trafficking. Mutations in this gene are associated with familial infantile myoclonic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2475118 - 2505734
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162065 (version 83.38)
Entrez gene	57465
UniProt	Q9ULP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULP9
Antibodypedia	TBC1D24 antibodies

PROTEIN BROWSER

TBC1D24-001	TBC1D24-002	TBC1D24-004	TBC1D24-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D24-001 ENSP00000454408 ENST00000567020	Q9ULP9 [Direct mapping] TBC1 domain family member 24 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0031175 [neuron projection development] GO:0031594 [neuromuscular junction] GO:0043195 [terminal bouton] GO:0043547 [positive regulation of GTPase activity] Show all	553 aa 62.3 kDa	No	0
TBC1D24-002 ENSP00000293970 ENST00000293970	Q9ULP9 [Direct mapping] TBC1 domain family member 24 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0031175 [neuron projection development] GO:0031594 [neuromuscular junction] GO:0043195 [terminal bouton] GO:0043547 [positive regulation of GTPase activity] Show all	559 aa 62.9 kDa	No	0
TBC1D24-004 ENSP00000457896 ENST00000562105	H3BV07 [Direct mapping] TBC1 domain family member 24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 6.1 kDa	No	0
TBC1D24-007 ENSP00000486121 ENST00000627285	Q9ULP9 [Direct mapping] TBC1 domain family member 24 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0031175 [neuron projection development] GO:0031594 [neuromuscular junction] GO:0043195 [terminal bouton] GO:0043547 [positive regulation of GTPase activity] Show all	553 aa 62.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.