Expression of ZFPL1 in cancer - Summary - The Human Protein Atlas

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ZFPL1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZFPL1
Gene description	Zinc finger protein-like 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA014909 , HPA017347
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014909	HPA017347

GENE INFORMATION
Gene name	ZFPL1 (HGNC Symbol)
Synonyms	D11S750, MCG4
Description	Zinc finger protein-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65084223 - 65088400
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162300 (version 83.38)
Entrez gene	7542
UniProt	O95159 (UniProt - Evidence at protein level)
neXtProt	NX_O95159
Antibodypedia	ZFPL1 antibodies

PROTEIN BROWSER

ZFPL1-001	ZFPL1-005	ZFPL1-006	ZFPL1-009	ZFPL1-011	ZFPL1-013	ZFPL1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZFPL1-001 ENSP00000294258 ENST00000294258	O95159 [Direct mapping] Zinc finger protein-like 1 A0A024R576 [Target identity:100%; Query identity:100%] Zinc finger protein-like 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] Show all	310 aa 34.1 kDa	No	1
ZFPL1-005 ENSP00000434454 ENST00000526334	E9PQ47 [Direct mapping] Zinc finger protein-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0008270 [zinc ion binding] Show all	188 aa 20.6 kDa	No	0
ZFPL1-006 ENSP00000432529 ENST00000526945	E9PQA5 [Direct mapping] Zinc finger protein-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0008270 [zinc ion binding] Show all	172 aa 18.9 kDa	No	0
ZFPL1-009 ENSP00000432377 ENST00000530488	H0YCU8 [Direct mapping] Zinc finger protein-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 6 kDa	No	0
ZFPL1-011 ENSP00000433673 ENST00000525509	E9PJX1 [Direct mapping] Zinc finger protein-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7.1 kDa	No	0
ZFPL1-013 ENSP00000437090 ENST00000532200	E9PNY1 [Direct mapping] Zinc finger protein-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0008270 [zinc ion binding] Show all	207 aa 22.7 kDa	No	0
ZFPL1-015 ENSP00000432833 ENST00000526791	E9PJX1 [Direct mapping] Zinc finger protein-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.