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Most cacner tissues displayed weak to moderate nuclear and cytoplasmic immunoreactivity. Several cases of colorectal cancers and squamous cell carcinomas showed strong staining.
GENE INFORMATION
Gene name
RPS6KA4 (HGNC Symbol)
Synonyms
MSK2, RSK-B
Description
Ribosomal protein S6 kinase, 90kDa, polypeptide 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
E9PJN1 [Direct mapping] Ribosomal protein S6 kinase
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MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)