We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
FGF19
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FGF19

Gene description

Fibroblast growth factor 19

Protein class

Cancer-related genes
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Secreted

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (CAPAN-2)
HPA (normal tissue):Tissue enriched (gallbladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular deposits and cytoplasmic expression in all tissues, including gallbladder.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA036082
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA036082

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most colorectal, ovarian and pancreatic cancers showed weak to moderate cytoplasmic and membranous staining. Testicular cancers generally showed moderate cytoplasmic positivity. Most of the remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

FGF19

Synonyms

Description

Fibroblast growth factor 19 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.3

Chromosome location (bp)

69698232 - 69704642

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162344 (version 83.38)

Entrez gene

9965

UniProt

O95750 (UniProt - Evidence at protein level)

neXtProt

NX_O95750

Antibodypedia

FGF19 antibodies

PROTEIN BROWSER

FGF19-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGF19-001
ENSP00000294312
ENST00000294312
O95750 [Direct mapping]
Fibroblast growth factor 19
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001755 [neural crest cell migration]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010629 [negative regulation of gene expression]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046326 [positive regulation of glucose import]
GO:0046330 [positive regulation of JNK cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070858 [negative regulation of bile acid biosynthetic process]
Show all
216 aa
24 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.