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Most colorectal, ovarian and pancreatic cancers showed weak to moderate cytoplasmic and membranous staining. Testicular cancers generally showed moderate cytoplasmic positivity. Most of the remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
FGF19
Synonyms
Description
Fibroblast growth factor 19 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]