Expression of ZYG11B in cancer - Summary - The Human Protein Atlas

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ZYG11B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZYG11B
Gene description	Zyg-11 family member B, cell cycle regulator
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA028156
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028156

GENE INFORMATION
Gene name	ZYG11B (HGNC Symbol)
Synonyms	FLJ13456, ZYG11
Description	Zyg-11 family member B, cell cycle regulator (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p32.3
Chromosome location (bp)	52726467 - 52827342
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162378 (version 83.38)
Entrez gene	79699
UniProt	Q9C0D3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9C0D3
Antibodypedia	ZYG11B antibodies

PROTEIN BROWSER

ZYG11B-001	ZYG11B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZYG11B-001 ENSP00000294353 ENST00000294353	Q9C0D3 [Direct mapping] Protein zyg-11 homolog B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0051438 [regulation of ubiquitin-protein transferase activity] Show all	744 aa 83.9 kDa	No	0
ZYG11B-201 ENSP00000441315 ENST00000545132	A8DPD7 [Direct mapping] Protein zyg-11 homolog B; ZYG11B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0051438 [regulation of ubiquitin-protein transferase activity] Show all	566 aa 63.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.