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ACOT11

GENERAL INFORMATION

Gene name

 ACOT11

Gene description

 Acyl-CoA thioesterase 11

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in intestines.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA041047
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041047

GENE INFORMATION

Gene name

 ACOT11 (HGNC Symbol)

Synonyms

 BFIT, BFIT1, KIAA0707, STARD14, THEA, THEM1

Description

 Acyl-CoA thioesterase 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Chromosome

 1

Cytoband

 p32.3

Chromosome location (bp)

 54542257 - 54639192

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162390 (version 83.38)

Entrez gene

 26027

UniProt

 Q8WXI4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXI4

Antibodypedia

 ACOT11 antibodies

PROTEIN BROWSER
ACOT11-001
ACOT11-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOT11-001
ENSP00000360366
ENST00000371316
Q8WXI4 [Direct mapping]
Acyl-coenzyme A thioesterase 11
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006631 [fatty acid metabolic process]
GO:0008289 [lipid binding]
GO:0009266 [response to temperature stimulus]
GO:0009409 [response to cold]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0035556 [intracellular signal transduction]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
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 607 aa
68.5 kDa 		No 0
ACOT11-002
ENSP00000340260
ENST00000343744
Q8WXI4 [Direct mapping]
Acyl-coenzyme A thioesterase 11
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006631 [fatty acid metabolic process]
GO:0008289 [lipid binding]
GO:0009266 [response to temperature stimulus]
GO:0009409 [response to cold]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0035556 [intracellular signal transduction]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
Show all
 594 aa
67.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.