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PARS2

GENERAL INFORMATION

Gene name

 PARS2

Gene description

 Prolyl-tRNA synthetase 2, mitochondrial (putative)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA028314 , HPA028518
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), colorectal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA028314
HPA028518

GENE INFORMATION

Gene name

 PARS2 (HGNC Symbol)

Synonyms

 DKFZp727A071

Description

 Prolyl-tRNA synthetase 2, mitochondrial (putative) (HGNC Symbol)

Entrez gene summary

 This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]

Chromosome

 1

Cytoband

 p32.3

Chromosome location (bp)

 54756898 - 54764514

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162396 (version 83.38)

Entrez gene

 25973

UniProt

 Q7L3T8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L3T8

Antibodypedia

 PARS2 antibodies

PROTEIN BROWSER
PARS2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PARS2-001
ENSP00000360327
ENST00000371279
Q7L3T8 [Direct mapping]
Probable proline--tRNA ligase, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004827 [proline-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006433 [prolyl-tRNA aminoacylation]
GO:0010467 [gene expression]
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 475 aa
53.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.