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Glucocorticoid modulatory element binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2011]
Q9Y692 [Direct mapping] Glucocorticoid modulatory element-binding protein 1 B1AT47 [Target identity:100%; Query identity:100%] Glucocorticoid modulatory element binding protein 1, isoform CRA_a; cDNA, FLJ96492, Homo sapiens glucocorticoid modulatory element binding protein 1(GMEB1), transcript variant 2, mRNA
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Predicted intracellular proteins Plasma proteins Transcription factors alpha-Helices exposed by beta-structures Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
Q9Y692 [Direct mapping] Glucocorticoid modulatory element-binding protein 1
Show all
Predicted intracellular proteins Plasma proteins Transcription factors alpha-Helices exposed by beta-structures Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
