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AK4

GENERAL INFORMATION

Gene name

 AK4

Gene description

 Adenylate kinase 4

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Hep G2)
HPA (normal tissue):Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA042753 , HPA049461
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable), cervical cancer (unfavourable), renal cancer (unfavourable), stomach cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001
Cervical cancer p<0.001
Renal cancer p<0.001
Stomach cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA042753
HPA049461

GENE INFORMATION

Gene name

 AK4 (HGNC Symbol)

Synonyms

 AK3, AK3L1

Description

 Adenylate kinase 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 65147549 - 65232145

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162433 (version 83.38)

Entrez gene

 205

UniProt

 P27144 (UniProt - Evidence at protein level)

neXtProt

 NX_P27144

Antibodypedia

 AK4 antibodies

PROTEIN BROWSER
AK4-001
AK4-007
AK4-201
AK4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AK4-001
ENSP00000322175
ENST00000327299
P27144 [Direct mapping]
Adenylate kinase 4, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0016776 [phosphotransferase activity, phosphate group as acceptor]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
GO:0070062 [extracellular exosome]
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 223 aa
25.3 kDa 		Yes 0
AK4-007
ENSP00000448458
ENST00000546702
D3DQ64 [Direct mapping]
Adenylate kinase 4, mitochondrial; HCG2031840, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046939 [nucleotide phosphorylation]
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 171 aa
19.8 kDa 		No 0
AK4-201
ENSP00000378743
ENST00000395334
P27144 [Direct mapping]
Adenylate kinase 4, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0007420 [brain development]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0016776 [phosphotransferase activity, phosphate group as acceptor]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0042493 [response to drug]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
GO:0070062 [extracellular exosome]
Show all
 223 aa
25.3 kDa 		Yes 0
AK4-202
ENSP00000445912
ENST00000545314
P27144 [Direct mapping]
Adenylate kinase 4, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004017 [adenylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006172 [ADP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0016776 [phosphotransferase activity, phosphate group as acceptor]
GO:0019205 [nucleobase-containing compound kinase activity]
GO:0046033 [AMP metabolic process]
GO:0046034 [ATP metabolic process]
GO:0046039 [GTP metabolic process]
GO:0046899 [nucleoside triphosphate adenylate kinase activity]
GO:0070062 [extracellular exosome]
Show all
 223 aa
25.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.