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JAK1

GENERAL INFORMATION

Gene name

 JAK1

Gene description

 Janus kinase 1

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB013088
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), colorectal cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB013088

GENE INFORMATION

Gene name

 JAK1 (HGNC Symbol)

Synonyms

 JAK1A, JAK1B, JTK3

Description

 Janus kinase 1 (HGNC Symbol)

Entrez gene summary

 Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 64833229 - 64966504

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162434 (version 83.38)

Entrez gene

 3716

UniProt

 P23458 (UniProt - Evidence at protein level)

neXtProt

 NX_P23458

Antibodypedia

 JAK1 antibodies

PROTEIN BROWSER
JAK1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
JAK1-001
ENSP00000343204
ENST00000342505
P23458 [Direct mapping]
Tyrosine-protein kinase JAK1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005131 [growth hormone receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007167 [enzyme linked receptor protein signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031730 [CCR5 chemokine receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0036016 [cellular response to interleukin-3]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0046677 [response to antibiotic]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
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 1154 aa
133.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.