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CTRC

GENERAL INFORMATION

Gene name

 CTRC

Gene description

 Chymotrypsin C (caldecrin)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (pancreatic cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (pancreas)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression as well as extracellular positivity in pancreas

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA046920
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA046920

GENE INFORMATION

Gene name

 CTRC (HGNC Symbol)

Synonyms

 CLCR, ELA4

Description

 Chymotrypsin C (caldecrin) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.21

Chromosome location (bp)

 15438439 - 15449242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162438 (version 83.38)

Entrez gene

 11330

UniProt

 Q99895 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99895

Antibodypedia

 CTRC antibodies

PROTEIN BROWSER
CTRC-001
CTRC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTRC-001
ENSP00000365116
ENST00000375949
Q99895 [Direct mapping]
Chymotrypsin-C
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008233 [peptidase activity]
GO:0009235 [cobalamin metabolic process]
GO:0044281 [small molecule metabolic process]
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 268 aa
29.5 kDa 		Yes 0
CTRC-201
ENSP00000365110
ENST00000375943
Q68DR9 [Direct mapping]
Chymotrypsin-C; Putative uncharacterized protein DKFZp779K0837
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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 69 aa
7.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.