Expression of FBLIM1 in cancer - Summary - The Human Protein Atlas

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FBLIM1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FBLIM1
Gene description	Filamin binding LIM protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic epxression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 1 antibody. HPA025287
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable), melanoma (unfavourable) and renal cancer (unfavourable).
Cervical cancer p<0.001 Melanoma p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025287

GENE INFORMATION
Gene name	FBLIM1 (HGNC Symbol)
Synonyms	CAL, FBLP-1, migfilin
Description	Filamin binding LIM protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.21
Chromosome location (bp)	15756607 - 15786594
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162458 (version 83.38)
Entrez gene	54751
UniProt	Q8WUP2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WUP2
Antibodypedia	FBLIM1 antibodies

PROTEIN BROWSER

FBLIM1-001	FBLIM1-002	FBLIM1-003	FBLIM1-004	FBLIM1-005	FBLIM1-006	FBLIM1-007	FBLIM1-008	FBLIM1-009	FBLIM1-010	FBLIM1-011	FBLIM1-012	FBLIM1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBLIM1-001 ENSP00000364926 ENST00000375771	Q8WUP2 [Direct mapping] Filamin-binding LIM protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0008270 [zinc ion binding] GO:0008360 [regulation of cell shape] GO:0016337 [single organismal cell-cell adhesion] GO:0031005 [filamin binding] GO:0033623 [regulation of integrin activation] GO:0034329 [cell junction assembly] Show all	373 aa 40.7 kDa	No	0
FBLIM1-002 ENSP00000364921 ENST00000375766	Q8WUP2 [Direct mapping] Filamin-binding LIM protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0008270 [zinc ion binding] GO:0008360 [regulation of cell shape] GO:0016337 [single organismal cell-cell adhesion] GO:0031005 [filamin binding] GO:0033623 [regulation of integrin activation] GO:0034329 [cell junction assembly] Show all	373 aa 40.7 kDa	No	0
FBLIM1-003 ENSP00000416387 ENST00000441801	Q8WUP2 [Direct mapping] Filamin-binding LIM protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0008270 [zinc ion binding] GO:0008360 [regulation of cell shape] GO:0016337 [single organismal cell-cell adhesion] GO:0031005 [filamin binding] GO:0033623 [regulation of integrin activation] GO:0034329 [cell junction assembly] Show all	374 aa 40.3 kDa	No	0
FBLIM1-004 ENSP00000364920 ENST00000332305	Q8WUP2 [Direct mapping] Filamin-binding LIM protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0008270 [zinc ion binding] GO:0008360 [regulation of cell shape] GO:0016337 [single organismal cell-cell adhesion] GO:0031005 [filamin binding] GO:0033623 [regulation of integrin activation] GO:0034329 [cell junction assembly] Show all	276 aa 30.8 kDa	No	0
FBLIM1-005 ENSP00000387595 ENST00000430076	Q5VVD3 [Direct mapping] Filamin-binding LIM protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 1.9 kDa	No	0
FBLIM1-006 ENSP00000423471 ENST00000508310	D6RA19 [Direct mapping] Filamin-binding LIM protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		34 aa 3.7 kDa	No	0
FBLIM1-007 ENSP00000402401 ENST00000431771	E7EPI5 [Direct mapping] Filamin-binding LIM protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11 kDa	No	0
FBLIM1-008 ENSP00000422862 ENST00000496928	D6R9V9 [Direct mapping] Filamin-binding LIM protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		30 aa 3.3 kDa	No	0
FBLIM1-009 ENSP00000421885 ENST00000510393	D6RAI6 [Direct mapping] Filamin-binding LIM protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.3 kDa	No	0
FBLIM1-010 ENSP00000421764 ENST00000510929	D6RAI8 [Direct mapping] Filamin-binding LIM protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		14 aa 1.5 kDa	No	0
FBLIM1-011 ENSP00000422075 ENST00000502638	D6R9I4 [Direct mapping] Filamin-binding LIM protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.4 kDa	No	0
FBLIM1-012 ENSP00000427052 ENST00000483633	E7EN81 [Direct mapping] Filamin-binding LIM protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 15.1 kDa	No	0
FBLIM1-013 ENSP00000424920 ENST00000502739	E7EWE8 [Direct mapping] Filamin-binding LIM protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	144 aa 15.9 kDa	No	0

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