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A majority of testicular cancers showed strong cytoplasmic positivity. Luminal membranes was accentuated in several cases of colorectal cancers. Skin cancers showed distinct cytoplasmic and membranous positivity in several cases. Most of the remaining malignancies were negative.
Malignant cells were generally negative. Distinct cytoplasmic and membranous staining was observed in several testicular cancers.
GENE INFORMATION
Gene name
PDPN (HGNC Symbol)
Synonyms
aggrus, Gp38, GP40, PA2.26, T1A-2
Description
Podoplanin (HGNC Symbol)
Entrez gene summary
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]