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DHRS3

GENERAL INFORMATION

Gene name

 DHRS3

Gene description

 Dehydrogenase/reductase (SDR family) member 3

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA010844
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DHRS3 (HGNC Symbol)

Synonyms

 RDH17, retSDR1, Rsdr1, SDR1, SDR16C1

Description

 Dehydrogenase/reductase (SDR family) member 3 (HGNC Symbol)

Entrez gene summary

 Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]

Chromosome

 1

Cytoband

 p36.21

Chromosome location (bp)

 12567910 - 12617731

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162496 (version 83.38)

Entrez gene

 9249

UniProt

 O75911 (UniProt - Evidence at protein level)

neXtProt

 NX_O75911

Antibodypedia

 DHRS3 antibodies

PROTEIN BROWSER
DHRS3-001
DHRS3-002
DHRS3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHRS3-001
ENSP00000480439
ENST00000616661
O75911 [Direct mapping]
Short-chain dehydrogenase/reductase 3
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001523 [retinoid metabolic process]
GO:0003151 [outflow tract morphogenesis]
GO:0004745 [retinol dehydrogenase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0030278 [regulation of ossification]
GO:0042572 [retinol metabolic process]
GO:0042622 [photoreceptor outer segment membrane]
GO:0048387 [negative regulation of retinoic acid receptor signaling pathway]
GO:0052650 [NADP-retinol dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0060021 [palate development]
GO:0060349 [bone morphogenesis]
GO:0060411 [cardiac septum morphogenesis]
Show all
 302 aa
33.5 kDa 		No 1
DHRS3-002
ENSP00000478218
ENST00000464917
A0A087WTY3 [Direct mapping]
Short-chain dehydrogenase/reductase 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 81 aa
8.6 kDa 		No 0
DHRS3-004
ENSP00000387903
ENST00000430996
Q5SUY4 [Direct mapping]
Short-chain dehydrogenase/reductase 3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 147 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.